The best advice that could be given to humanity.
Created with Trimble Sketchup: http://www.sketchup.com/
SketchUp tutorial on how to make this thing in Getting Started with MakerBot: http://shop.oreilly.com/product/0636920026723.do
Print, share and enjoy.
There are holes in the corners if you want to hang the sign.
Pictures show the sign printed in translucent red Ultimachine PLA.
layer height: 0.25
travel feedrate: 55
I found that If you crank up the feedrate / travel feedrate, the "O" in "Don't Panic!" comes out very sloppy.